This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Longitudinal Assessment of Bariatric Surgery (LABS) has been designed as a prospective and longitudinal cohort study. The primary objectives of LABS-2 are to describe surgical risks and changes in clinical, metabolic, and psychosocial measures among patients undergoing bariatric surgery. Risks and changes occurring within 3 years of surgery will be assessed using standardized techniques and measures in a multi-center cohort of patients to determine the associations of clinical and demographic patient characteristics, components of the surgical procedure, peri-operative and post-operative care with post-operative risks and changes in clinical, metabolic, and psychosocial measures. The secondary objectives are to assess health care utilization of patients undergoing bariatric surgery for treatment of obesity and related co-morbidities. We will also obtain and store biospecimens (serum, plasma, whole blood) for research related to the aims of this study, and for future research into the pathophysiology and genetics of obesity and obesity related complications.evaluate the long-term efficacy of weight loss surgery and assess how well weight control surgery reduces body weight and improves health conditions related to obesity: risk stratification, weight loss and body composition, diabetes mellitus and insulin resistance, cardiovascular and pulmonary disease, renal disease, liver function and gastrointestinal disease, behavioral factors, musculoskeletal and functional status, gender issues, nutrient deficiencies, economic impact, and biospecimens. Extensive data collection and follow-up will allow LABS-2 to identify long-term safety and efficacy (up to 3 years) outcomes, both risks and benefits, and to determine their associations with patient, surgical, and post-surgical care characteristics.
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