This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the research study is to examine the growth hormone (GH) responsiveness in children with chronic kidney disease (CKD) who are exhibiting growth retardation. Growth retardation is a common condition in children with CKD and is thought to be caused predominantly by disturbances of the growth hormone-insulin-like growth factor (GH/IGF-I) axis. The hypothesis of the study is that measuring IGF-I concentrations produced in response to different doses of exogenous growth hormone therapy will allow the prediction of growth hormone responsiveness and consequently enable growth hormone doses to be tailored for each individual. This is a multi-center, prospective, randomized, open label, pilot study. Thirty participants with chronic kidney disease and short stature or poor growth velocity will be enrolled and will receive study treatment for 56 weeks following an 8 week observation period (64 week total study duration).
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