This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot project is a single center study in which 10 adolescents with bipolar disorder will participate in a 20 week course of adjunctive psychotherapy with Interpersonal and Social Rhythm Therapy (IPSRT; Frank et al., 2000)(12 weekly sessions plus 4 biweekly sessions). In an effort to examine the adaptability and feasibility of this treatment, participants will complete a treatment satisfaction measure every 4 treatment sessions. In addition, a brief symptom assessment battery (i.e., Mania Rating Scale; Beck Depression Inventory; Brief Psychiatric Rating Scale for Children) will be completed on a monthly basis to monitor participants' clinical status during treatment. This research project is the first part of the PI's Mentored Patient-Oriented Career Development Award to develop the PI's skills conducting clinical trials of psychosocial interventions for adolescents with mood disorders. This research project consists of a 10-case psychotherapy development and standardization study aimed at adapting an empirically-supported adjunctive psychotherapy for adults with bipolar disorder (Interpersonal and Social Rhythm Therapy, IPSRT; Frank et al., 2000) to the treatment of adolescents with bipolar disorder. This study will enable the PI to: 1) integrate developmentally-informed engagement strategies and interpersonal focus areas into the psychosocial treatment of adolescents with bipolar disorder; 2) identify specific strategies to incorporate the family in the adolescent's treatment; 3) obtain a series of representative case examples for inclusion in the manual; 4) optimize the battery of instruments used to assess symptoms of mania and depression and psychosocial functioning in adolescents; 5) begin the iterative process of developing a treatment manual; 6) develop treatment adherence and competence measures that are tied directly to the material in the manual; and 7) develop measures of treatment acceptability for patients and parents.
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