This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Two common familial forms of hypertriglyceridemia exist: monogenic familial hypertriglyceridemia (FHTG) and familial combined hyperlipidemia (FCHL). FCHL is associated with premature coronary artery disease; FHTG is not associated with premature coronary disease. At present, there are no effective uncomplicated methods for distinguishing between individuals with these two disorders. FHTG has been suggested to have defective intestinal transport of bile acids after a meal. It is hypothesized that bile acids will be lower in FHTG than in FCHL after gall bladder contraction with cholecystokinin. We will test this hypothesis by comparing serum levels of cholic acid and chenodeoxycholic acid in 12 subjects with FHTG to levels in 12 patients with FCHL. If the range of values is sufficiently different, this could lead to the development of a diagnostic test to distinguish between these groups and facilitate preventative treatment of FCHL patients who are at high risk of premature coronary artery disease.
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