This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Repeated urinary tract infections (UTIs) are a very common problem in young healthy women. One possible but unproven method of preventing repeat UTIs is by drinking cranberry juice cocktail. The purpose of this study is to determine what effect different amounts of cranberry juice cocktail have on the urine's ability to prevent bacteria from sticking to bladder cells, which is how cranberry juice cocktail is thought to possibly prevent UTIs. This will be accomplished by assigning women randomly (like flipping a coin) to drink different amounts of artificially sweetened cranberry juice cocktail (2 oz to 16 oz), and then studying their urines in the laboratory to see whether they reduce the 'stickiness' of bacteria to bladder cells. The study is done twice for each person, once with food and once on an empty stomach. Participants are asked to collect their urine at 4,8,12 and 24 hour intervals after they drink the cranberry juice. Premenopausal women 18-45 years of age with at least one UTI in the past year are eligible for the study. Participants can have no antibiotic use in the past 7 days prior to enrollment and no UTI symptoms, such as burning on urination. In addition, they cannot be pregnant, have an allergy to cranberry juice or have a history of kidney stones. Women enrolled will be asked to avoid all foods containing cranberries (other than the study product), blueberries and lingonberries.
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