This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this study is to examine the immediate and long-term effects of two relaxation and suggestion procedures on pain and pain interference relative to each other and to a no-treatment baseline (four or eight weeks in length, depending on the patient's condition) in a group of 294 individuals with disability (up to 134 with spinal cord injury, and 160 pilots: 20 with amputation, 40 with multiple sclerosis, 20 with cerebral palsy, 20 with neuromuscular disease, 20 with post-polio syndrome, 20 post-stroke patients with pain, and 20 with neuropathic pain) who report bothersome disability-related pain. Study participants with SCI will be randomly assigned to one of two treatment conditions: (1) 'Relaxation 1' which is a relaxation training condition that will include some components common to hypnosis (focusing on a visual cue, suggestions for relaxation) as well as suggestions for perceived analgesia or (2) 'Relaxation 2' which is a relaxation training condition that will include only one component common to hypnosis (focusing on a visual cue) plus biofeedback for reduction of muscle tension. Pilot study participants with MS will be randomly assigned to one of two treatment conditions: (1) the Relaxation 1 condition described above, or (2) a traditional relaxation training condition that incorporates progressive muscle relaxation. The rest of the pilot participants will be enrolled in the Relaxation 1 condition described above. The primary outcome variable (pain intensity) and secondary outcome variables (pain interference, medical services utilization, depression, and perceived pain control) are all assessed via telephone interviews.
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