This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will characterize the pathophysiology and course of glomerular injury in patients with various glomerulopathies. The investigators hypothesize that alterations in the glomerular capillary wall (GCW) pore-size structure (loss of pore density and changes in pore size distribution) are the ultimate cause of hypofiltration and proteinuria, and that progressive azotemia is the result of progressive injury to the GCW itself.
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