Abstract

The primary objective of this study is to determine the effects of combined nicotinic acid and chromium chloride supplementation on serum levels of total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglycerides and high-density lipoprotein cholesterol in normal volunteers. The primary hypothesis to be tested is that combined therapy with low dose nicotinic acid and CrCl3 will result in a significant reduction in serum levels of total cholesterol. The secondary hypotheses are, 1) combined therapy with low dose nicotinic acid and CrCl3 will result in a significant reduction in LDL-C, VLDL-C, and TG, and a significant increase in HDL-C; 2) combined therapy with low dose nicotinic acid and CrCl3 will result in a significant improvement in glucose tolerance, and a significant reduction in fasting glucose, and insulin levels. 3) The changes in lipid and glucose parameters will be greater in those subjects with suboptimal dietary Cr intakes. 4) There will be significant positive correlation between serum and urinary measurements of chromium and niacin and dietary levels of these nutrients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000040-36
Application #
5216100
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
36
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Khalili, Mandana; Shuhart, Margaret C; Lombardero, Manuel et al. (2018) Relationship Between Metabolic Syndrome, Alanine Aminotransferase Levels, and Liver Disease Severity in a Multiethnic North American Cohort With Chronic Hepatitis B. Diabetes Care 41:1251-1259
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Evon, Donna M; Wahed, Abdus S; Johnson, Geoffrey et al. (2016) Fatigue in Patients with Chronic Hepatitis B Living in North America: Results from the Hepatitis B Research Network (HBRN). Dig Dis Sci 61:1186-96
Park, Jang-June; Wong, David K; Wahed, Abdus S et al. (2016) Hepatitis B Virus--Specific and Global T-Cell Dysfunction in Chronic Hepatitis B. Gastroenterology 150:684-695.e5
Hering, Bernhard J; Clarke, William R; Bridges, Nancy D et al. (2016) Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia. Diabetes Care 39:1230-40
Leonard, Mary B; Shults, Justine; Long, Jin et al. (2016) Effect of Low-Magnitude Mechanical Stimuli on Bone Density and Structure in Pediatric Crohn's Disease: A Randomized Placebo-Controlled Trial. J Bone Miner Res 31:1177-88
Ricordi, Camillo; Goldstein, Julia S; Balamurugan, A N et al. (2016) National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 65:3418-3428

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