The APL 400-020 series of vaccines are specially-constructed DNA plasmid-based vaccines which have been developed as genetic vaccines for the treatment of human cutaneous T cell lymphoma (CTCL). These vaccines, each of which is directed at a specific variable region of the (Beta)-chain of human T cell receptors, are designed to provoke immune responses against the clone of malignant T cells that express the (Beta)-chain variable region to which they are targeted. this study will be a single-center, open-label, Phase I clinical trial that is designed to evaluate the safety of APL 400-020 Vaccines when administered individually in multiple, fixed doses to CTCL patients with T cell tumors containing V(Beta) chains that match the V(Beta) gene family to which the response provoked in CTCL patients by comparing certain immune response parameters pre- and post-injection. The study will also provide for monitoring indicators of progression or regression of CTCL.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000040-38A1
Application #
6274499
Study Section
Project Start
1998-04-15
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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