EXCEED THE SPACE PROVIDED.This is an application for a five year renewal of the General Clinical Research Center (GCRC) at theUniversity of Pennsylvania Medical Center. The GCRC is used as a multidisciplinary resource within theinstitution. Investigators from the Departments of Medicine, Surgery, Obstetrics and Gynecology,Epidemiology and Biostatistics, Molecular and Cellular Engineering, Dermatology, Psychiatry, Neurology,Radiology, Physical Medicine and Rehabilitation, Biochemistry, Pharmacology, and Pediatrics arerepresented in current protocols. The University has fostered translational research by the development oftransdepartmental Centers and Institutes. Amongst those active in the GCRC are the Institute for HumanGene Therapy (IHGT), the Center for Experimental Therapeutics (GET), the Center for Epidemiology andBiostatistics, the Center for Sleep and Respiratory Neurobiology, the Center for Womens' Health, theInstitute for Neurosciences, and the Functional Brain Imaging Center for the Study of Mental Disorders.Several of these entities, such as the IHGT and the GET have been founded since the last renewal and havebecome major users of the GCRC. A core laboratory provides diversified analytical support for protocolsperformed on the GCRC, as do dietetic services and the metabolic kitchen. There is a core CDMAS, whichis also utilized by investigators from the Children's Hospital GCRC. Increasingly,the GCRC is used as afocal point for teaching programs focused on patient-oriented medical research involving medical students,residents and fellows. Thus, the GCRC at the University of Pennsylvania plays a central arid critical role intranslational and clinical research and in the training of new investigators in patient-oriented research at theinstitution.University of Pennsylvania Medical Center (UPMC)General Clinical Research Center3400 Spruce Street160 DullesPavilionPhiladelphia, PA 19104-4283KEY PERSONNEL See instructions on PageNameAsbury, Arthur K. M.D.FitzGerald, Garret, M.D.Rader, Daniel, M.D.Teff, Karen, Ph.D.Tovvnsend, Raymond, M.D.il.use continuation pages as needed to provide Organization Dean, School of Medicine UPMC UPMC,GCRC UPMC, GCRC UPMC, GCRC UPMC, GCRCPHS 398 (Rev. 4/98) Page 2002/1the required information in the format shown below. Role on Project Principal Investigator Program Director Associate Program Director Associate ProgramDirector Associate Program DirectorBB'
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