The overall objective of this proposal is to evaluate the role of Type I glucocorticoid receptors (MR) in the hippocampus and septum in the regulation of the HPA axis studies which have utilized the synthetic glucocorticoid, dexamethasone. The research proposed has 4 objectives: 1) Confirm that a single dose of corticosterone which suppresses HPA axis secretion is operating through mineralcorticoid receptors (MR) and evaluate the plasma pharmacokinetics of corticosterone. 2) Examine the effects of an MR antagonist (spironolactone) on ACTH and cortisol secretion and the zenith and nadir of the circadian rhythm of the HPA axis. 3) Compare the HPA axis responses to corticosterone and the plasma pharmacokinetics in depressed patients and controls, and 4) examine the relationship between the DST result and the response to corticosterone, and specific patient and illness characteristics [age, sex, family history of mood disorder, cumulative history of depression, severity of depression, and duration of episode].

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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