This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Excess weight around the waist is associated with poor blood vessel function and increased cardiovascular risk. However, the mechanism is unclear. A substance in the body called angiotensinogen II may play a role. By blocking the production of angiotensinogen II with a medication called valsartan, blood vessel function may be improved in people ages 18-50 who have excess abdominal girth and are otherwise healthy. Brachial artery flow-mediated dilatation, forearm plethysmography, cutaneous laser doppler blood flow and computerized arterial pulse waveform analysis will be used to study the responses of the blood vessels. Subjects will be randomly given both valsartan and placebo at different times to determine if candesartan improves blood vessel function.
Showing the most recent 10 out of 1380 publications
