This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Tourette syndrome (TS) is a common disorder characterized by multiple motor and vocal tics. TS is associated with Obsessive-Compulsive behaviors (OCB) and attention-deficit disorder. The brain abnormalities in TS are unknown. The suppression of tics by drugs that block the action of dopamine suggests that excessive action or release of dopamine in some brain region causes tics. We propose to investigate the brain abnormalities of TS by using non-invasive imaging methods with positron emission tomography (PET) to evaluate brain dopamine function. Specifically, we are searching for evidence of excessive dopamine from nerve endings in the striatum, a major target of brain dopamine nerve cells. We will study 30 subjects with TS and 30 controls.'
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