This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of the study is to identify genetic or inherited factors that may increase the risk of bleeding in the brain for people who are taking warfarin, a drug that thins a person's blood. We hope to use the results of this study to find better ways to predict who is at increased risk for bleeding in the brain (ICH-intracranial hemorrhage) while taking warfarin so that doctors can take this into account when deciding how to prescribe the drug. Over a five-year period, 2750 people are expected to participate, 550 from University of Michigan (UM). This will include 250 (50 from UM) who have had ICH who are on warfarin, and 1000 (200 from UM) who have had ICH who are not on warfarin. It also includes healthy subjects who have not had ICH for comparison. We plan to have 500 (100 from UM) healthy subjects who are on warfarin, and 1000 (200 from UM) healthy subjects who are not on warfarin. Participants in this study will be asked to complete an interview to obtain health information about their own and their family medical history. They will be asked to donate three tubes of blood. The blood will be tested to look for factors that might increase the risk of ICH when warfarin is taken. Although this research may lead to better understanding of the reason that ICHs occur, the participants will derive no personal benefit from participation in this project.'
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