This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this research study is to collect blood from pairs of brothers with prostate cancer in order to do laboratory studies. These laboratory studies will look for genes (factors that can be inherited) that might influence the risk of prostate cancer. Cancer researchers have recently identified several biological factors that may be important in the development of prostate cancer. Researchers will determine the role of more than two dozen genetic factors in cancer research. We will also specifically study whether there is any relationship between any of these genetic factors and the risk of developing prostate cancer. Cancer researchers have come to appreciate that the risk of getting cancer may be increased because of inherited genes. Sometimes the risk can be very strong; sometimes the risk is relatively weak. We are studying whether many genes with weak contributions to cancer risk can interact to produce a strong risk.The purpose of this study is to gather allele-sharing statistics at approximately 25 candidate loci throughout the human genome most likely to influence genetic risk of prostate cancer, to perform fine structure multipoint analysis for candidate genes/regions showing suggestive evidence for linkage, to perform a marker-guided strategy for testing gene x gene interactions in disease and to identify disease variants within candidate genes in appropriate patient subsets.
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