This study will compare the durability of viral load response following 48 week treatment w/1592U89/ZDV/3TC vs. ZDV/3TC, assess the safety and tolerance of these combinations. It will also compare the clinical efficacy of the two regimens as determined by survival, disease progression, weight velocity and neuropsychological or neurological changes, assess the viral resistance in a subset of subjects, characterize the steady-state plasma levels of 1592U89 across the subjects between 3 months to 13 yrs of age, evaluate the changes in drug pharmacokinetics.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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