This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Creatine is a naturally occuring compound obtained by humans from production withing the body and through the diet. When supplemented with creatine, muscle levels of creatine increase and this has shown benefits with regards to muscle strength in young, healthy volunteers, animal-based models of disease and in some patient populations. The purpose of this study is to better understand how creatine enters muscle and help identify why certain individuals do not respond to creatine therapy. To help understand how creatine enters muscle, a technique called nuclear magnetic resonance spectroscopy (MRS) will be used to monitor muscle creatine changes over time, the MRS technique is commonly used to diagnose diseases or injuries to tissue. One to two healthy volunteers and/or one elderly volunteer will be asked to participate in this study to test if MRS is sensitive enough to detect changes in muscle creatine after a single oral dose.
Showing the most recent 10 out of 782 publications
