This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Purpose: A growing body of epidemiological data suggests an increased risk of cardiovascular events associated with air pollutants. Reactive oxygen species (ROS) have been implicated as a potential mechanism for the adverse effects of air pollutants and genetic polymorphisms of theglutathione-s-transferases (GSTs) have been shown to participate in the antioxidant defenses to air pollutants. The first part of this protocol is a pilot study to identify the optimum diesel exhaust concentration to investigate the cardiovascular effects in healthy older subjects. The main part of this proposal is to examine the health effects of diesel exhaust exposure on thecardiovascular system and to examine whether omega-3 fatty acid supplement pretreatment would attenuate the adverse cardiovascular effects. We will also determine whether healthy older subjects with GSTM1 positive genotype have a lower cardiovascular risk than the subjects with GSTM1 null genotype when exposed to diesel exhaust.
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