This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
Study aims are to: 1) Evaluate presence of the systemic inflammatory marker hsCRP in osteoarthritis (OA) patients who have had a total hip arthroplasty (THA) compared to matched total hip arthroplasty OA-THA control patients who do not have periprosthetic osteolysis; 2) Evaluate presence of elevated serum inflammatory markers and pro-osteoclast signaling proteins with the presence of osteolysis in OA-THA patients compared to OA-THA controls who do not have osteolysis; 3) OA-THA patients with osteolysis have an absent/ decreased history of bisphosphonate medication use than matched non-osteolytic OA-THA controls; and 4) OA-THA patients with osteolysis have a history of an increased frequency/ duration of high-impact activities such as running, jogging or walking, when compared to matched non-osteolytic OA-THA controls.Hypothesis: 1) OA patients who require THA revision due to periprosthetic osteolysis have evidence of systemic inflammation, evidence by elevated serum hsCRP levels not present in matched OA-THA controls without osteolysis, or in OA THA patients undergoing hip revision surgery for reasons other than osteolysis; 2) Inflammatory mediators and pro-osteoclast signaling proteins are elevated in the sera of OA-THA patients with osteolysis, and are not elevated in OA-THA patients without osteolysis, or in OA-THA patients who require hip revision surgery for reasons other than osteolysis; 3) OA-THA patients with osteolysis have an absent/ decreased history of bisphosphonate medication use than matched non-osteolytic OA-THA controls; 4) OA-THA patients with osteolysis have a history of an increased frequency/ duration of high-impact activities such as running, jogging, walking, when compared to matched non-osteolytic OA-THA controls.
Showing the most recent 10 out of 370 publications
