The cysteinyl leukotrienes are products of the 5 lipoxgenase pathway of arachidonic acid metabolism and are synthesized by mast cells, basophils, macrophages, and eosinophils. The objectives are 1) to determine the effectiveness of 3 different doses of pranlukast and placebo at inhibiting leukotriene-D4 induced bronchoconstriction, 2) to characterize the relationship B/N plasma concentrations of pranlukast and inhibition of LTD4-induced bronchocons. And 3) to evaluate the safety of the various intravenous doses of pran. during inhalation.
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| Lertratanakul, Apinya; Wu, Peggy; Dyer, Alan R et al. (2014) Risk factors in the progression of subclinical atherosclerosis in women with systemic lupus erythematosus. Arthritis Care Res (Hoboken) 66:1177-85 |
| Nodzenski, Michael; Muehlbauer, Michael J; Bain, James R et al. (2014) Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data. Bioinformatics 30:3287-8 |
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