This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obstructive sleep apnea (OSA) occurs in 4% of males and 2% of females in the general population and reports indicate that the disastrous cardio-respiratory outcomes occur during the perioperative management of patients with OSA. Postoperative episodic, nocturnal hypoxemia with oxygen saturation 85% and prolonged episodes of myocardial ischemia during nocturnal hypoxemia has been documented in healthy patients undergoing elective abdominal surgery. Patients with OSA have been reported to experience airway obstruction following minimal doses of sedatives and anesthetic agents and deaths have been reported in the literature attributed to OSA and anesthesia. While there is an increased awareness among anesthesiologists regarding the vulnerability of these patients, there is a lack of consensus regarding the perioperative care of these patients. It has been suggested that all OSA patients be closely monitored postoperatively, but clinical experience demonstrates that not all patients with OSA need intensive monitoring. It is anticipated that the data from this study will successfully identify the patient with OSA who is at risk for postoperative complications and result in the establishment of strict selection criteria for patients who require intensive monitoring and development and implementation of evidence based guidelines for safe and effective management of these patients.
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