This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 2 diabetes mellitus, formerly known as adult onset diabetes and non-insulin dependent diabetes, is being described with increased frequency in the child and adolescent population. The increased prevalence of type 2 diabetes has paralleled the increase in obesity noted in the pediatric population. As in the adult population, there appears to be an increase in type 2 diabetes in minority populations, such as African American, Hispanic, and Native Americans. Abnormalities in insulin sensitivity and insulin secretion are found in adults with type 2 diabetes. Little data is available on the pathophysiology of type 2 diabetes seen in adolescents or on successful preventive and therapeutic interventions. In this project, we propose to test the following hypotheses to provide new insights concerning the pathogenesis of type 2 diabetes in adolescents, and to establish a framework for the development of appropriate screening strategies and new preventive therapeutic interventions. HYPOTHESES: A. Type 2 diabetes in adolescents is characterized by severe insulin resistance and defects in beta cell function. B. Adolescents with acanthosis nigricans and varying degrees of glucose tolerance are characterized by severe insulin resistance and defects in beta cell function. C. Adolescents with insulin resistance have evidence of early risk factors for later cardiovascular disease.
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| Slama, Laurence; Jacobson, Lisa P; Li, Xiuhong et al. (2016) Longitudinal Changes Over 10 Years in Free Testosterone Among HIV-Infected and HIV-Uninfected Men. J Acquir Immune Defic Syndr 71:57-64 |
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| Arroyo-Ávila, Mariangelí; Santiago-Casas, Yesenia; McGwin Jr, Gerald et al. (2015) Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol 34:1217-23 |
| Lertratanakul, Apinya; Wu, Peggy; Dyer, Alan R et al. (2014) Risk factors in the progression of subclinical atherosclerosis in women with systemic lupus erythematosus. Arthritis Care Res (Hoboken) 66:1177-85 |
| Nodzenski, Michael; Muehlbauer, Michael J; Bain, James R et al. (2014) Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data. Bioinformatics 30:3287-8 |
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