Abstract

Lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) are enzymes located on the surface of capillary endothelia. These two lipases act to remove triglyceride from the ore of circulating lipoprotein particles to initiate remodeling into smaller, denser forms. Xenical is a drug which, taken orally, inhibits gastric and pancreatic lipase activity by binding irreversibly to these enzymes to decrease intestinal fat absorption. Xenical may inhibit systemic lipases such as LPL and HTGL as well as gastrointestinal lipases. This study will investigate the effect of xenical and/or its metabolites on plasma LPL and HTGL activities in the fasted state and during the postprandial period.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000051-35
Application #
5218197
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Jensen, Thomas; Bjornstad, Petter; Johnson, Richard J et al. (2018) Copeptin and Estimated Insulin Sensitivity in Adults With and Without Type 1 Diabetes: The CACTI Study. Can J Diabetes :
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