This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This purpose of this study is to look at the effects of immunotherapy. A number of people who have allergy shots experience significant relief of their allergy symptoms. Some do not have any benefit, but continue to get the shots for up to a year or more anyway, as their symptoms may improve or worsen with the changes in seasonal aeroallergens. Because we do not understand exactly how allergy shots work, we do not currently have a test to measure their efficacy. Predicting early on whether a person will benefit, could save the non-responders unnecessary shots. It would also allow the treating physician to alter the immunotherapy sooner so a potentially more beneficial mix could be tried. Understanding how shots work may in the future allow us to measure the composition of a person ??s allergy specific immune proteins (antibodies) before immunotherapy is started to help us predict who is most likely to benefit
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