This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Peripheral arterial occlusions, manifest in the lower extremities of patients with peripheral arterial disease (PAD), restrict blood flow in response to exercise. The resulting blood flow/metabolic demand mismatch results in muscle ischemia, claudication pain, and an impaired functional walking ability. Previous work has identified the relevance of a metabolic component in the PAD exercise impairment. This is in contrast to the poor correlative data between exercise capacity and hemodynamic measures in these patients. Therefore, the present study is designed to evaluate the speed at whick leg muscle oxygen consumption increases to accommodate an exercise stress in PAD. Twenty subjects (10 PAD, 10 control) will be enrolled in this study. Measures of leg oxygen uptake kinetics, tissue hemoglobin saturation, and blood flow will be assessed during repeated bouts of calf exercise. Alterations in the exercise response of these markers and their relationship to the blood flow limitation will further describe the pathophysiology of PAD and may identify potential targets for future therapeutic application.
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