This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Over 400,000 total knee arthroplasties are performed each year in the United States to alleviate pain and disability associated with knee osteoarthritis. While total knee arthroplasty (TKA) reliably reduces pain and improves function in patients with knee osteoarthritis, recovery of quadriceps force to normal levels is rare. Walking performance remains about 20-30% lower than healthy age-matched older adults years after TKA, and more physically demanding tasks such as stair climbing are almost 50% lower. Within the past few years, minimally invasive TKA has emerged as a promising alternative to traditional TKA, in part because of less surgical trauma to the quadriceps. Early results from retrospective cohort comparisons indicate that minimally invasive TKA reduces hospital stays, decreases postoperative pain, and enables individuals to return to functional activities more quickly than traditional TKA. Yet, minimally invasive TKA is not without risks: decreased visualization during surgery can compromise prosthesis alignment and negatively impact surgical outcomes. To date, no randomized clinical trials have been reported comparing outcomes between minimally invasive and traditional TKA surgeries. The primary goal of this study is to provide support for a future randomized controlled clinical trial to determine if minimally invasive TKA improves quadriceps muscle force production and activation, increases knee range of motion, and decreases post-operative pain to improve functional outcomes compared to traditional TKA. Fifty patients (ages 50-85 years) who qualify for minimally invasive TKA will be randomized to receive either a traditional TKA or a minimally invasive TKA. Baseline testing will be performed before surgery and after surgery at 48hrs, 1, 3, 6 months, 1 year and 2 years. With a growing number of older adults requiring total knee arthroplasties each year, the consequences of quadriceps weakness and resulting disability after TKA present a growing health problem, which minimally invasive TKA surgery has the potential to mitigate.
Showing the most recent 10 out of 1065 publications
