Childhood obstructive sleep apnea syndrome (OSAS) appears to be due to a combination of structural and neuromotor factors. It is thought that those children who develop OSAS due to adenotonsillar hypertrophy have additional underlying abnormalities. Magnetic resonance imaging (MRI) studies have shown that adults with OSAS have narrow upper airways compared to controls. It is therefore possible that those children with adenotonsillar hypertrophy and OSAS have narrower upper airways than children with large tonsils but no OSAS. MRI's have also been useful in adults to demonstrate the degree of adipose tissue encroachment on the upper airway. In children, MRIs can be used to measure the size of the upper airway, and establish whether upper airway narrowing, if present, is due to skeletal structures, adipose tissue or lymphoid tissue (tonsils and adinodis). We therefore performed MRIs of the upper airway in 4 children with OSAS (3) of whom received CPAP therapy) and 2 controls. Two studies were technically inadequate due to patient motion (sedation cannot be used in children with OSAS). In the remaining subjects, children with OSAS had smaller upper airways than controls. These very preliminary data suggest that children with OSAS have small pharyngeal airways, and suggest that the patients may be at risk of recurrence of OSAS in later life, should they develop additional risk factors.
| Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521 |
| Salemi, Parissa; Skalamera Olson, Julie M; Dickson, Lauren E et al. (2018) Ossifications in Albright Hereditary Osteodystrophy: Role of Genotype, Inheritance, Sex, Age, Hormonal Status, and BMI. J Clin Endocrinol Metab 103:158-168 |
| Robert Braši?, James; Mari, Zoltan; Lerner, Alicja et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6: |
| Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866 |
| AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786 |
| Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671 |
| Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72 |
| Al-Sofiani, Mohammed E; Yanek, Lisa R; Faraday, Nauder et al. (2018) Diabetes and Platelet Response to Low-Dose Aspirin. J Clin Endocrinol Metab 103:4599-4608 |
| Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429 |
| Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451 |
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