Anxiety disorders are relatively frequent in the pediatric population and are responsible for significant morbidity. We are currently conducting a clinical trial of fluvoxamine treatment of childhood and adolescent-onset anxiety disorders, specifically separation anxiety disorder, generalized anxiety disorder, and social phobia. This study is an opportunity to utilize a molecular genetic research design to study the genetics of anxiety in a pediatric population. This proposed study will examine three primary associations: 1) the presence of childhood-onset anxiety disorders and serotonin (5HT) related candidate genes, 2) temperament and 5HT related genes, and 3) response of childhood anxiety to treatment with fluvoxamine and 5HT related genes. Identification of specific genetic factors may lead to advanced prevantative and treatment strategies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000052-39
Application #
6412028
Study Section
Special Emphasis Panel (ZRR1)
Project Start
1975-10-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
39
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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