Using [11C]raclopride, a radioligand already demonstrated to be affected by dopamine (DA) release from methylphenidate and ampetamine (AMP) studies, this study will observe a decrease in Bmax measures with AMP challenge in both schizophrenic (SCZ) patients and normal controls. Through the appropriate PET imaging protocol it is expected that the magnitude of the decrease in Bmax to be greater in SCZ patients than in the controls. It is also expected that there will be no significant change in NMSP binding with AMP challenge in either. Each subject will first have Bmax measurement (2 PET scans) with raclopride or NMSP (saline), followed by a repeat of the same Bmax measurement (2 PET scans) but with AMP rather than saline. No patients will be taken off of medication for research purposes alone. Patients will be carefully selected who have either voluntarily or for purposes of clinical care been taken off medication. Normal will be recruited through the Nuclear medicine pool and will have to pass drug screening as well as tests done in the physical.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000052-39
Application #
6412303
Study Section
Special Emphasis Panel (ZRR1)
Project Start
1975-10-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
39
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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