During the year 1995-1996, the Outpatient GCRC has been of indispensable value for the follow-up of men with adrenomyeloneuropathy (AMN). This follow-up study has four major objectives: 1) Define the phenotype and clinical course in untreated AMN patients. We had found in the previous year, with the support of the OPD-GCRC, that AMN can be subdivided into two major categories on the basis of Magnetic Resonance Imaging (MRI) studies. The AMN patients with normal MRI have essentially normal cognitive function and an excellent long- term prognosis. The peripheral nerve abnormalities in AMN are attributable mainly to axonal involvement rather than demyelination. 2) Clarify the pathogenesis of Adrenoleukodystophy (ALD). The main significant finding during the last year was the demonstration that the inflammatory demyelinating lesions in the rapidly progressive forms of ALD differ from those in multiple sclerosis in respect to cytokine pattern and HLA linkage. The nature of the inflammatory response was also clarified by the application of the magnetization transfer imaging technique. 3) A major goal of the studies is the evaluation of dietary therapy with """"""""Lorenzo's Oil"""""""". This study required precise knowledge or the natural progression of the disease (the topic of objective 1), and a multidisciplinary appraisal of the clinical course in treated patients. This is in progress. 4) It has been noted that a moderate reduction of platelet count is a common side effect of Lorenzo Oil therapy. As reported in publication 5, we have shown that the reduction of platelet count is correlated with the level of erucic acid in platelets. This study has provided us with a strategy to monitor and manage this side effect.
| Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521 |
| Salemi, Parissa; Skalamera Olson, Julie M; Dickson, Lauren E et al. (2018) Ossifications in Albright Hereditary Osteodystrophy: Role of Genotype, Inheritance, Sex, Age, Hormonal Status, and BMI. J Clin Endocrinol Metab 103:158-168 |
| Robert Braši?, James; Mari, Zoltan; Lerner, Alicja et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6: |
| Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866 |
| AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786 |
| Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671 |
| Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72 |
| Al-Sofiani, Mohammed E; Yanek, Lisa R; Faraday, Nauder et al. (2018) Diabetes and Platelet Response to Low-Dose Aspirin. J Clin Endocrinol Metab 103:4599-4608 |
| Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429 |
| Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451 |
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