Male hypogonadism has been associated with signs and symptoms of sexual dysfunction, decreased body hair, and osteoporosis. At present, there are several androgen preparations available in the United States. These include injectable testosterone esters, two oral preparations, fluoxymesterone and methyl-testosterone, and two types of transdermal androgen patches presently available. However, each has its own disadvantages for testosterone supplementation. The most significant disadvantage involves the prostate. Testosterone can increase the prostate size leading to benign prostate hypertrophy (BPH), especially in older men. In looking for an improved androgen delivery system as well as an androgen that would be safer for elderly men, a testosterone derivative, dihydrotestosterone (DHT) 1% hydroalcholic gel (DHT-gel) has been developed to allow transdermal application over broad areas of skin in measured fashion without visible identifying patches. This method uses natural testosterone products and allows a measured dose to be dispensed, which then can be rubbed, on to a given area of skin by the user. The gel liquefies and the alcohol rapidly evaporate leaving an unrecognizable film of testosterone on the skin which is then rapidly incorporated into the epidermal tissue. There is no sticky residue. Results from the phase I testing of DHT-gel indicate that the daily application of 64 grams of gel (100 mg T) to the upper arm/shoulder and trunk region yields stable DHT levels. No evidence of skin irritation was found in patients with T-gel in the phase I study. This study showed some very promising data that the size of prostate did not increase and some decrease in size.
| Aboud, Katherine S; Barquero, Laura A; Cutting, Laurie E (2018) Prefrontal mediation of the reading network predicts intervention response in dyslexia. Cortex 101:96-106 |
| Kattan, Meyer; Bacharier, Leonard B; O'Connor, George T et al. (2018) Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy. J Allergy Clin Immunol Pract 6:1596-1603.e6 |
| Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521 |
| Salemi, Parissa; Skalamera Olson, Julie M; Dickson, Lauren E et al. (2018) Ossifications in Albright Hereditary Osteodystrophy: Role of Genotype, Inheritance, Sex, Age, Hormonal Status, and BMI. J Clin Endocrinol Metab 103:158-168 |
| Robert BraĊĦi?, James; Mari, Zoltan; Lerner, Alicja et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6: |
| Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866 |
| AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786 |
| Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671 |
| Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72 |
| Al-Sofiani, Mohammed E; Yanek, Lisa R; Faraday, Nauder et al. (2018) Diabetes and Platelet Response to Low-Dose Aspirin. J Clin Endocrinol Metab 103:4599-4608 |
Showing the most recent 10 out of 1014 publications
