African American children living in the inner city are twice as likely to be hospitalized from asthma and five times as likely to die from asthma. Results from the National Cooperative Inner-City Asthma Study (NCICAS) indicate that 77% of inner-city homes have excessive cockroach allergen concentrations. Cockroach allergen reduction, therefore, has potential public health benefits if it can be shown to affect disease morbidity. The purpose of this study is to examine the effect of cockroach extermination and cleaning on asthma morbidity in children living in the inner city of Baltimore. One hundred asthmatic children who are allergic to cockroaches will be recruited. Qualifying children enter a Baseline Phase during which they undergo an initial evaluation of symptoms, skin testing, spirometry and methacholine challenge testing. Sera will be collected for IgE and IgG antibody to cockroach. A home visit assesses roach infestation, and to measure indoor allergens in settled dust. Next, families are randomly selected to receive active treatment (insecticide, mattress covers and commercial cleaning) or to enter a control group. The control group receives no treatment until the completion of the trial. Bimonthly clinic visits continue for the next 6 months. Home visits continue every other month to inspect, set roach sticky trap samplers and collect household dust for allergen anaylsis. Methacholine challenge and serology will be repeated at 6 months. Control patients will receive extermination and cleaning at the end of the trial.
| Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521 |
| Salemi, Parissa; Skalamera Olson, Julie M; Dickson, Lauren E et al. (2018) Ossifications in Albright Hereditary Osteodystrophy: Role of Genotype, Inheritance, Sex, Age, Hormonal Status, and BMI. J Clin Endocrinol Metab 103:158-168 |
| Robert Braši?, James; Mari, Zoltan; Lerner, Alicja et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6: |
| Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866 |
| AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786 |
| Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671 |
| Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72 |
| Al-Sofiani, Mohammed E; Yanek, Lisa R; Faraday, Nauder et al. (2018) Diabetes and Platelet Response to Low-Dose Aspirin. J Clin Endocrinol Metab 103:4599-4608 |
| Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429 |
| Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451 |
Showing the most recent 10 out of 1014 publications
