The obstructive sleep apnea syndrome (OSAS) is a common cause of morbidity in childhood. Arousal from sleep during airway obstruction has been regarded as a protective reflex that reestablishes airway patency and prevents severe, life-threatening asphyxia. Termination of an obstructive apnea by arousal has been clearly shown in adults. Children, in contrast, often do not have cortical arousals in association with apneas. It is unclear whether this lack of arousal in children is due to a general defect in arousal mechanisms, or to more specific defects. We have previously shown that children with OSAS have blunted arousal responses to respiratory stimuli, such as hypercapnia and increased inspiratory resistance. However, it is not known whether these arousal deficits to respiratory stimuli are due to blunting of the arousal response secondary to chronic nocturnal hypercapnia and upper airway obstruction, or whether they are due to an intrinsic abnormality in the arousal response. We hypothesized that children with OSAS have a generalized deficit of arousal mechanisms. The objective of this study is to analyze whether the overall arousal threshold is abnormal, by evaluating the arousal response to a non-respiratory (acoustic) stimulus. In this study, children with OSAS and age-matched controls will undergo a nocturnal sleep study during which electrocortical arousal to a graded acoustic stimulus will be evaluated. These experiments will help elucidate the underlying pathophysiology of childhood OSAS, resulting ultimately in improved management of this disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000052-41
Application #
6590512
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
41
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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