This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cross-sectional study designed to (1) comprehensively evaluate the prevalence of abnormalities in glucose metabolism, serum lipid levels, body composition, fat deposition and distribution, and bone density in vertically HIV-infected and HIV-uninfected children and youth, (2) evaluate whether exposure to PIs is correlated with the metabolic and morphologic abnormalities among HIV-infected children and youth, and (3) compare the prevalence of abnormalities in this population according to Tanner Stage. These data are critical for designing intervention trials and studies designed to study pathophysiologic mechanisms. A total of 450 subjects will be enrolled.
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