This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposed the administration of two doses of rituximab 375 mg/m2 prior to cyclophosphamide 50 mg/kg/d for four days. Rituximab is being administered prior to cyclophosphamide to achieve maximal lymphoid reduction. It will then be followed by cyclophosphamide 50 mg/kg/d for four days in an effort to achieve maximal cytoreduction of the mature plasma cells. Once hematopoietic recovery occurs, rituximab will be given weekly times four at the time when the myeloma burden should be lowest, immediately following high dose therapy and then every three months for 3 doses to further eliminate residual myeloma stem cells which may be present. Patients are eligible for this study if they have primary refractory or relapsed Multiple Myeloma after prior therapy, and have Durie-Salmon Stage II or III disease at any time since diagnosis. Additional eligibility criteria include sensitivity to salvage therapy, age >18 years, FEV > 50%, FVC > 50%, normal left ventricular cardiac ejection fraction, and chromosome 13 deletion.
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| Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72 |
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| Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429 |
| Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451 |
| Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504 |
| Aboud, Katherine S; Barquero, Laura A; Cutting, Laurie E (2018) Prefrontal mediation of the reading network predicts intervention response in dyslexia. Cortex 101:96-106 |
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