This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Longitudinal and cross-sectional studies of postmenopausal women indicate that performance on tasks of memory improves following estrogen replacement therapy (Sherwin, 2002 for a review; Duka T et al, 2000; Smith YR et al, 2001; Maki et al, 2001). Recently, the use of plant-derived products rich in isoflavone phytoestrogens, known to exert weak estrogenic action, have been shown to improve performance in young men and women on tests of short- and long-term memory (File et al., 2001). The purpose of the present study is to determine if the use of Revival, a popular dietary supplement containing naturally occurring isoflavones, leads to improved memory function in postmenopausal women. We propose to conduct a double-blind, placebo-controlled investigation of the effects of an isoflavone dietary supplement, Revival, taken for 12 weeks, on a neuropsychological test battery that includes assessment of memory function in 100 postmenopausal women (50 women randomized to receive Revival, 50 women randomized to receive placebo). We hypothesize that the ingestion of Revival will result in superior memory performance in postmenopausal women in a manner similar to that seen with estrogen replacement therapy, and consistent with reports in eugonadal subjects.
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