This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. I. Overarching Goal: To acquire preliminary data for a larger study using structural magnetic resonance imaging, magnetic resonance spectroscopy, and neuropsychological tests to compare individuals with traumatic brain injury (TBI) who develop Major Depression for the first time after TBI (cases) to those who do not develop Depression after TBI (controls).
Specific Aims of The Proposed Study To compare patterns of brain injury and brain dysfunction as assessed by: (1) structural magnetic resonance imaging, (2) magnetic resonance spectroscopy and (3) neuropsychological testing, in traumatic brain injury (TBI) subjects with negative past history of mood disorder who have developed Major Depression for the first time after TBI (cases) to those who have not developed Major Depression after TBI (controls). Hypotheses: 1) When examined using T2 weighted magnetic resonance imaging (MRI), TBI patients with depression, when compared to those without depression, have more number and volume of brain lesions in: (a) left dorso-lateral frontal region and (b) left basal ganglia. 2) When examined using magnetic resonance spectroscopy, TBI patients with depression, when compared to those without depression, have decreased N-acetyl aspartate (NAA) levels and increased choline levels in: (a) left dorso-lateral frontal and (b) left basal ganglia regions. 3) When examined using neuropsychological testing, TBI patients with depression, when compared to those without depression, exhibit greater impairment in tests sensitive to frontal functioning.
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