The objective of this randomized, double-blind, active-controlled pilot study was to compare the effects of the angiotensin II receptor antogonist irbesartan (IRBE) with amlodipine (AML) in hypertensive (Ht) {seated systolic BP(SeDBP) 90-110 mmHg or treatment (Rx) for Ht} patients (pts) with type II diabetic nephropathy. Forty seven pts were randomized to receive either 75 mg IRBE or 2.5 mg AML (od,po) for 12 weeks. Doses were doubled at weeks 4 and 8.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000054-36A1
Application #
6245525
Study Section
Project Start
1997-05-01
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
36
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
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