In these studies, we will define the patterns and natural history of insulin secretion in kidney-pancreas transplant recipients. The transplanted pancreas is a unique human model in which to study beta cell function since the pancreas is situated in an abnormal anatomic site, drains into the systemic rather than the portal circulation, and has been severed from it central neurological connections. The proposed studies will define the quantitative and qualitative alterations in insulin secretion which occur in these patients.

Project Start
1999-12-01
Project End
2001-02-28
Budget Start
Budget End
Support Year
39
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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