EXCEED THE SPACEPROVIDED.The mission of the combined adult and pediatric General Clinical Research Center (GCRC) at the Universityof Chicago is to provide the resources, infrastructure and training for faculty to conduct outstandingtranslational research which will cure diseases and maintain the health of all people. The GCRC aims tocreate an environment in which this research is conducted in a safe and ethically sound manner. It is ouraim to promote the optimal collaboration among basic researchers and clinical scientists to translate thefindings at the bench to improved health at the bedside. Our areas of concentration include: (1) theunderstanding for the molecular basis for asthma, inflammatory bowel disease, cardiomyopathy,polycysticovary syndrome, metabolic bone disease and new thyroid diseases; (2) the Diagnosis, Prevention andTreatment of Diabetes Mellitus and other Metabolic Syndromes; (3) Treatment and Diagnosis of SubstanceAbuse and Stress and (4) Physiology and pathology of sleep as it relates to obesity, ageing, pregnancy andother conditions. Additional areas of concentration include novel treatments for recurrent pregnancy loss;treatment of lung disease and septic shock. We submit 60 protocols from 34 different investigators (20 ofwhom have NIH funding) from 8 different specialties. We are requesting support for a Sleep andChronobiology Core that would support 15 protocols. Without GCRC support these protocols cannot beperformed. The request includes a core manager and a 0.5 FTE sleep technician as well as equipmentnecessary to conduct the studies. We are also requesting continued support for the Biostatistician andStatistical Geneticist to review all protocols. The University purchased for the GCRC an automated DNAextractor to keep pace with the large scale genotyping requested by our investigators. We are requestingcontinued support for laboratory personnel to meet this demand. We anticipate developing a curriculum withthe NIH and the World Health Organization to train scientists from other countries in the area of clinicalresearch. Together these requests will allow the GCRC to fulfill its mission of providing the very best inoutstanding translational research for the public good.
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| Garyu, Justin W; Meffre, Eric; Cotsapas, Chris et al. (2016) Progress and challenges for treating Type 1 diabetes. J Autoimmun 71:1-9 |
| Rosenfield, Robert L (2015) The Polycystic Ovary Morphology-Polycystic Ovary Syndrome Spectrum. J Pediatr Adolesc Gynecol 28:412-9 |
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| Copinschi, Georges; Leproult, Rachel; Spiegel, Karine (2014) The important role of sleep in metabolism. Front Horm Res 42:59-72 |
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