This study investigates the long term inter-relationships between alternative modalities of therapy in depression to try and define predictors of optimal response. This investigation will pursue 3 specific aims: 1)to characterize psychobiologic correlates of depressive syndromes that are differentially responsive to supportive counseling (SC), cognitive behavioral therapy (CBT) and pharmacotherapy with sertraline (SRT); 2)to ascertain the relative efficacy of CBT and SRT as compared to SC and placebo-controlled and; & 3)to further clarify the state dependence (i.e., reversibility) or state independence (i.e., irreversibility) of selected psychobiologic correlates by studying patients longitudinally.

Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
1996
Total Cost
Indirect Cost
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