The primary objectives of this protocol are to assess the safety of SCH58500 when given as a single intratumoral dose to a patient with p53 mutant head and neck squamous cell carcinoma and also assess the biological activity of SCH58500 by confirming wild type p53 gene expression, as measured by reverse transcription and polymerase chain reaction (RT-PCR) in treated tumor tissue. The secondary objective is to assess clinical evidence of antitumor efficacy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000056-38S1
Application #
6114578
Study Section
Project Start
1978-12-01
Project End
2003-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
38
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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