This is a randomized study evaluating alternative immunization strategies in patients with metastatic melanoma. Patients will be immunized with one of the P1-P3 or P5 peptides (100ug). IL-12 will be given subcutaneously at 30 (Tier 1), 100 (Tier 2), or 300 (Tier 3) ng/kg at a location adjacent to the peptide. All patients will also be vaccinated with HLA-A2 presented recall antigen (influenza A matrix (Flu M1 58-66: GILGFVFTL) peptide at a contralateral site.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000056-39
Application #
6304655
Study Section
Special Emphasis Panel (ZRR1)
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
39
Fiscal Year
2000
Total Cost
$3,034
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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