This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis to be tested by this project is that THC produces characteristic changes in the activity of the human brain, both at rest and during the performance of cognitive and perceptual-motor tasks that are measurable using functional magnetic resonance imaging (fMRI) measures of blood flow and neuronal activity. We further propose that the behavioral and physiological effects of THC and marijuana in humans are due to a unique pattern of brain regions engaged following acute drug administration, and that the two will be related in time and magnitude. We have completed studies in the following areas: We have determined the effects of 3 doses of THC on brain activity, which included findings of a dose-dependent changes in activity in several brain regions and that THC administration decreased brain activation by a series of cognitive and motor tasks. In addition we have measured in real-time, the subjective effects of THC in subjects undergoing scanning and used them to investigate changes in brain activity associated with them.
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