This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Congenital heart defects occur in the US in approximately 5-8 of every 1000 live born children. In Wisconsin, there is an estimated 400-600 new cases each year. While the cause of most congenital heart defects is unknown, they constitute a significant public health concern with estimated costs in the first year of life frequently exceeding $50,000 per child. The Wisconsin Pediatric Cardiac Registry is a registry of children born in the state of Wisconsin since 1/1 2000 with a congenital heart defect. It is a database of genetic and environmental exposure information provided by families. It is hypothesized that the accumulation of combined genetic and environmental information on patients with structural congenital heart disease will be of utility in elucidating the etiology of these disorders. Families are asked to participate by completing a comprehensive 35-page questionnaire that inquires into family history of congenital heart and other defects and possible exposures prior to and during this pregnancy. A subset of families, based on the infant's diagnosis is asked to participate in blood or buccal swab DNA sampling.
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