Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will investigate the efficacy of task-activated fMRI as a biomarker for quantifying a therapeutic response in Parkinson's Disease (PD).
The specific aims are to: (1) determine the sensitivity of task-activated fMRI for detecting changes in brain activation patterns occurring in PD patients on and off dopaminergic replacement therapy, (2) compare the relative sensitivity to therapeutic response of task-activated fMRI compared to established clinical outcome measures, and (3) determine the test-retest reliability of task-activated fMRI in healthy older adults.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000058-45
Application #
7375103
Study Section
Special Emphasis Panel (ZRR1-CR-2 (01))
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
45
Fiscal Year
2006
Total Cost
$43,756
Indirect Cost

  Institution

Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226

  Publications

Eastman, Meridith L; Verhulst, Brad; Rappaport, Lance M et al. (2018) Age-Related Differences in the Structure of Genetic and Environmental Contributions to Types of Peer Victimization. Behav Genet 48:421-431
Das, Emon K; Lai, Pui Y; Robinson, Austin T et al. (2018) Regular Aerobic, Resistance, and Cross-Training Exercise Prevents Reduced Vascular Function Following a High Sugar or High Fat Mixed Meal in Young Healthy Adults. Front Physiol 9:183
Reiter, Katherine; Nielson, Kristy A; Durgerian, Sally et al. (2017) Five-Year Longitudinal Brain Volume Change in Healthy Elders at Genetic Risk for Alzheimer's Disease. J Alzheimers Dis 55:1363-1377
Conant, Lisa L; Liebenthal, Einat; Desai, Anjali et al. (2017) The relationship between maternal education and the neural substrates of phoneme perception in children: Interactions between socioeconomic status and proficiency level. Brain Lang 171:14-22
Fernandino, Leonardo; Humphries, Colin J; Conant, Lisa L et al. (2016) Heteromodal Cortical Areas Encode Sensory-Motor Features of Word Meaning. J Neurosci 36:9763-9
Fernandino, Leonardo; Binder, Jeffrey R; Desai, Rutvik H et al. (2016) Concept Representation Reflects Multimodal Abstraction: A Framework for Embodied Semantics. Cereb Cortex 26:2018-34
Lancaster, Melissa A; Seidenberg, Michael; Smith, J Carson et al. (2016) Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer's Disease. J Int Neuropsychol Soc 22:1005-1015
Nelson, Lindsay D; Guskiewicz, Kevin M; Barr, William B et al. (2016) Age Differences in Recovery After Sport-Related Concussion: A Comparison of High School and Collegiate Athletes. J Athl Train 51:142-52
Rao, Stephen M; Bonner-Jackson, Aaron; Nielson, Kristy A et al. (2015) Genetic risk for Alzheimer's disease alters the five-year trajectory of semantic memory activation in cognitively intact elders. Neuroimage 111:136-46
Sannagowdara, Kumar; Willoughby, Rodney; Whelan, Harry (2015) Proton Nuclear Magnetic Resonance (NMR) Metabolomics: Future in Etiological Diagnosis of Encephalomyelitis. J Neuroinfect Dis 6:

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