Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Current guidelines for the initial treatment of HIV-1 infection provide a number of options to subjects and providers. Durable improvements in virologic and immunologic parameters are observed in the majority of naive subjects for each of the recommended regimens. As newer treatment strategies and drugs become available it is important to critically assess their role in the management of HIV-1 infection. This study will examine the use of a lopinavir/ritonavir (a ritonavir-enhanced, second-generation protease inhibitor)-based regimen, a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen, and a nucleoside-sparing regimen for the initial treatment of HIV-1 infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000059-45
Application #
7377007
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-03-01
Project End
2007-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
45
Fiscal Year
2006
Total Cost
$13,258
Indirect Cost

  Institution

Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Rao, Satish S C; Valestin, Jessica A; Xiang, Xuelian et al. (2018) Home-based versus office-based biofeedback therapy for constipation with dyssynergic defecation: a randomised controlled trial. Lancet Gastroenterol Hepatol 3:768-777
Curtis, Alexandra M; VanBuren, John; Cavanaugh, Joseph E et al. (2018) Longitudinal associations between dental caries increment and risk factors in late childhood and adolescence. J Public Health Dent 78:321-328
Lorenz, Douglas J; Levy, Steven; Datta, Somnath (2018) Inferring marginal association with paired and unpaired clustered data. Stat Methods Med Res 27:1806-1817
Oweis, Reem Reda; Levy, Steven M; Eichenberger-Gilmore, Julie M et al. (2018) Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study. Community Dent Oral Epidemiol 46:527-534
Curtis, A M; Cavanaugh, J E; Levy, S M et al. (2018) Examining caries aetiology in adolescence with structural equation modelling. Community Dent Oral Epidemiol 46:258-264
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Choo-Wosoba, Hyoyoung; Gaskins, Jeremy; Levy, Steven et al. (2018) A Bayesian approach for analyzing zero-inflated clustered count data with dispersion. Stat Med 37:801-812
Levy, Steven M; Eichenberger-Gilmore, Julie M; Warren, John J et al. (2018) Associations of fluoride intake with children's cortical bone mineral and strength measures at age 11. J Public Health Dent 78:352-359
Oleson, Jacob J; Cavanaugh, Joseph E; McMurray, Bob et al. (2017) Detecting time-specific differences between temporal nonlinear curves: Analyzing data from the visual world paradigm. Stat Methods Med Res 26:2708-2725
Kwon, Soyang; Janz, Kathleen F; Letuchy, Elena M et al. (2017) Association between body mass index percentile trajectories in infancy and adiposity in childhood and early adulthood. Obesity (Silver Spring) 25:166-171

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