This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 18.8 million American adults suffer from a depressive disorder. The primary treatment for these disorders are antidepressants, of which the selective serotonin reuptake inhibitors (SSRIs) are considered first line. Half of patients started on antidepressant therapy discontinue their medications due to side effects. Sexual dysfunction is a significant problem in patients taking an SSRI, and often leads to their decision to discontinue treatment. Premature discontinuation of therapy is often done without the prescriber's knowledge, and results in a huge economic burden to our health care system, as these patients continue to suffer from untreated depression. Approximately 40-70% of patients taking an SSRI experience sexual dysfunction. Recent studies have found a relationship between polymorphisms in the serotonin transporter (5-HTT) and SSRI response. Very little is available regarding the relationship between these polymorphisms and SSRI side effects, which are thought to be related to serotonin transmission. This suggests that the 5HTT polymorphism may also be related to this adverse event. This pilot study will investigate the relationship between polymorphisms in the serotonin transporter and sexual dysfunction in subjects 18-40 years of age taking an SSRI for depression, who are currently in remission of their depression. The results of this cross sectional study will guide future prospective analyses of this relationship to determine individuals at a higher risk for experiencing adverse events, such as sexual dysfunction, from SSRI therapy. Identifying genetic factors related to sexual dysfunction may help to reduce the non-adherence seen with antidepressant treatment.
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