This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Auditory hallucinations (AHs) are very common (50-70%) in persons with schizophrenia. AHs are often reported as very distressing, especially if they are negative and/or intrusive. In about 25% of persons with schizophrenia who experience AHs, the AHs respond only partially or not at all to medication therapy. Effective treatment alternative for these AHs would therefore provide a significant benefit to patients and their communities. Recent studies have shown that two new promising teatment technologies, repetitive transcranial magnetic stimulation (rTMS) and Cognitive Behavior Therapy (CBT), for schizophrenia are effective for many patients with previously treatment-refractory AHs. We hypothesize that rTMS combined with CBT in the management of auditory hallucinations will result in greater treatment response than monotherapy with either modality and that the effects will be of significantly greater duration.
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