This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Available evidence suggests that there exists a substantial burden of occult myocardial infarctions (MI), particularly in type 2 diabetic patients. Contrast enhanced MRI (ceMRI) of myocardium reliably and reproducibly identifies MI and reflects the histopathological changes of MI; it identifies occult MI approximately twice as frequently as other invasive or noninvasive techniques. The prevalence and the risk factors associated with occult MI are unknown. Pilot data will be collected for a subsequent larger scale study to quantify the burden of occult MI using ceMRI. Approximately 30 patients with diabetes for >5 years duration will be enrolled, 50 to 80 years of age without clinical history of coronary disease. Furthermore, associations between occult MI and other factors will be investigated (health status, comorbidity, endothelial dysfunction, serum biomarkers).
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